ISSN  2587-2362  |  E-ISSN  2618-642X

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Biomarkers For Acute Kidney Injury [Int J Med Biochem ]
Int J Med Biochem . Ahead of Print: IJMB-09719 | DOI: 10.14744/ijmb.2018.09719

Biomarkers For Acute Kidney Injury

Dildar Konukoglu
Department of Medical Biochemistry, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey

Acute kidney injury (AKI) is associated with both a number of adverse outcomes and morbidity and mortality. Therefore, early diagnosis of AKI is very important. Several novel AKI biomarkers have been found and studied. Markers can be indicated impaired filtration barriers, reduced tubular reabsorption, increased release of tubular proteins due to cell damage and /or activation of inflammatory cells and release of activation products in response to injury. Among biomarkers in AKI neutrophil gelatinase–associated lipocalin, kidney injury molecule 1, interleukin-18, liver type fatty acid–binding protein, cystatin C, tissue inhibitor of metalloproteinase-2, and IGF-binding protein 7 are seem to be more useful for the early clinical outcomes in AKI. However, the clinical uses of AKI biomarkers are not defined very well and clinical trials are also limited. Additionally, analytical validation of the tests for AKI markers is also required. Therefore The measurement of amount of urine in daily and determination of blood urea and creatinine levels are used for the both diagnosis and classification of AKI in the majority of the clinical practice.

Keywords: Acute kidney injury, neutrophil gelatinase–associated lipocalin, kidney injury molecule 1, interleukin-18, liver type fatty acid–binding protein, cystatin C, tissue inhibitor of metalloproteinase-2, and IGF-binding protein 7



Corresponding Author: Dildar Konukoglu, Türkiye
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