ISSN  2587-2362  |  E-ISSN  2618-642X
Serum irisin levels are correlated with insulin resistance in women with gestational diabetes mellitus [Int J Med Biochem ]
Int J Med Biochem . 2020; 3(2): 91-95

Serum irisin levels are correlated with insulin resistance in women with gestational diabetes mellitus

Nilufer Celik
Department of Biochemistry, Dr. Behcet Uz Children’s Research and Training Hospital, Izmir, Turkey

INTRODUCTION: The aim of this study was to determine the serum irisin level in pregnant women with gestational diabetes mellitus (GDM) and those with a normal glucose tolerance test (NGT).
METHODS: Forty-three pregnant women who underwent a 50-g glucose challenge test (GCT) at 24-28 gestational weeks were included the study. If the serum glucose level result of the 50-g GCT was >140 mg/dL, a 100-g oral glucose tolerance test (OGTT) was applied. Diagnosis of GDM was confirmed if any 2 of the blood glucose test results were above the following levels: fasting serum glucose ≥92 mg/dL, 1-hour glycemia ≥180 mg/dL, or 2-hour glycemia ≥153 mg/dL. Patients with a result below this value were accepted as NGT. Nine pregnant patients with 50-g GCT results below 140 mg/dL and 5 pregnant women with a history of chronic hypertension were excluded. The remaining 29 pregnant women underwent a 100-g OGTT and were divided into 2 groups according to their results: 15 had GDM and 14 had a NGT. Maternal serum irisin was measured using an enzyme immunoassay method. The correlation between biochemical and demographic parameters and the serum irisin level in all participants were analyzed.
RESULTS: There were no significant difference between the GDM and NGT groups in terms of the maternal serum irisin level (8.71±1.34 µg/mL vs 8.17±1.01 µg/mL; p>0.32). The levels of fasting insulin, fasting glucose, and the 2-hour glucose level, as well as the homeostatic model assessment of insulin resistance (HOMA-IR) results of patients with GDM were higher than those of the NGT group. The maternal serum irisin level of the GDM subjects were positively and significantly correlated with the HOMA-IR value (r: 0.65; p<0.05), fasting insulin level (r: 0.44; p<0.05), and body mass index (BMI) (r: 0.81; p<0.05). A negative but significant correlation between the serum irisin level and diastolic blood pressure of the GDM subjects was also seen. Insignificant associations were found between the HOMA-IR score, fasting insulin level, BMI, and the serum irisin level of the NGT subjects.
DISCUSSION AND CONCLUSION: The maternal serum irisin level may regulate the HOMA-IR value, fasting insulin level, and diastolic blood pressure in women with GDM.

Keywords: Body mass index, gestational diabetes mellitus, homeostatic model assessment of insulin resistance, irisin, insulin

Nilufer Celik. Serum irisin levels are correlated with insulin resistance in women with gestational diabetes mellitus. Int J Med Biochem . 2020; 3(2): 91-95

Corresponding Author: Nilufer Celik, Türkiye
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