ISSN  2587-2362  |  E-ISSN  2618-642X

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International Journal of Medical Biochemistry The relationship between homocysteine and autoimmune subclinical hypothyroidism [Int J Med Biochem ]
Int J Med Biochem . Ahead of Print: IJMB-13008 | DOI: 10.14744/ijmb.2019.13008

The relationship between homocysteine and autoimmune subclinical hypothyroidism

Mehmet Bolal1, Ihsan Ates1, Burak Furkan Demir1, Mustafa Altay2, Turan Turhan3, Nisbet Yılmaz1
1Department of Internal Medicine, Sağlık Bilimleri University Ankara City Hospital, Ankara, Turkey
2Department of Endocrinology, Sağlık Bilimleri University Ankara City Hospital, Ankara, Turkey
3Department of Biochemistry, Sağlık Bilimleri University Ankara City Hospital, Ankara, Turkey

INTRODUCTION: Homocysteine, an atherosclerotic marker, is thought to be associated with chronic inflammation and autoimmunity. We aimed to investigate association of homocysteine level, lipid parameters, hs-CRP with autoantibodies in subclinical hypothyroid patients
METHODS: A total of 100 cases, 50 being above 18 years of age and diagnosed with subclinical hypothyroidism due to Hashimoto’s thyroiditis and 50 being healthy volunteers with no known disease, were included in the study
RESULTS: In our study, homocysteine (9.6 µmol/L versus 5.5 µmol/L; p<0.001), high sensitive c-reactive protein (hs–CRP) (2.4 mg/L vs 0.9 mg/L; p<0.001) and low density lipoprotein-cholesterol level (115.9±32.7 mg/dL vs 100.3±23.9 mg/dL, respectively; p=0.008) were determined to be higher and high density lipoprotein-cholesterol level (51.2±12.7 mg/dL versus 58.8±15.2 mg/dL, respectively; p=0.008) was determined to be lower in the subclinical hypothyroidism group compared to the healthy control group. A positive correlation was determined between homocysteine level and hs-CRP (r=0.312, p=0.027), anti–thyroid peroxidase (r=0.505, p<0.001) and anti-thyroglobulin (r=0.318, p=0.031) levels in the subclinical hypothyroidism group.
DISCUSSION AND CONCLUSION: In the regression analysis performed, high density lipoprotein–cholesterol, hs-CRP and homocysteine levels were each determined to be an independent risk factor for subclinical hypothyroidism.In our study, homocysteine was found to be associated with subclinical hypothyroidism.

Keywords: atherosclerosis, autoimmunity, Hashimoto Disease, homocysteine



Corresponding Author: Burak Furkan Demir, Türkiye
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