INTRODUCTION: Homocysteine, an atherosclerotic marker, is thought to be associated with chronic inflammation and autoimmunity. We aimed to investigate association of homocysteine level, lipid parameters, hs-CRP with autoantibodies in subclinical hypothyroid patients
METHODS: A total of 100 cases, 50 being above 18 years of age and diagnosed with subclinical hypothyroidism due to Hashimotos thyroiditis and 50 being healthy volunteers with no known disease, were included in the study
RESULTS: In our study, homocysteine (9.6 µmol/L versus 5.5 µmol/L; p<0.001), high sensitive c-reactive protein (hsCRP) (2.4 mg/L vs 0.9 mg/L; p<0.001) and low density lipoprotein-cholesterol level (115.9±32.7 mg/dL vs 100.3±23.9 mg/dL, respectively; p=0.008) were determined to be higher and high density lipoprotein-cholesterol level (51.2±12.7 mg/dL versus 58.8±15.2 mg/dL, respectively; p=0.008) was determined to be lower in the subclinical hypothyroidism group compared to the healthy control group. A positive correlation was determined between homocysteine level and hs-CRP (r=0.312, p=0.027), antithyroid peroxidase (r=0.505, p<0.001) and anti-thyroglobulin (r=0.318, p=0.031) levels in the subclinical hypothyroidism group.
DISCUSSION AND CONCLUSION: In the regression analysis performed, high density lipoproteincholesterol, hs-CRP and homocysteine levels were each determined to be an independent risk factor for subclinical hypothyroidism.In our study, homocysteine was found to be associated with subclinical hypothyroidism.