ISSN  2587-2362  |  E-ISSN  2618-642X
International Journal of Medical Biochemistry Evaluation of serum levels of irisin and nesfatin-1 in patients with migraine without aura [Int J Med Biochem ]
Int J Med Biochem . 2020; 3(2): 67-72 | DOI: 10.14744/ijmb.2020.30301

Evaluation of serum levels of irisin and nesfatin-1 in patients with migraine without aura

Turan Akdag1, Faruk Omer Odabas2
1Department of Plant and Animal Production, Meram Vocational School, Necmettin Erbakan University, Konya, Turkey
2Department of Neurology, Konya Education and Research Hospital, University of Health Science Konya, Turkey

INTRODUCTION: Migraine is a chronic neurological disorder. A number of cytokines have been linked to the pathogenesis of migraine. This is a preliminary assessment to determine and analyze the serum levels of irisin and nesfatin-1 in patients with migraine without aura.

METHODS: A total of 80 participants, 40 patients who had been diagnosed with migraine without aura (10 men, 30 women) and 40 healthy controls (10 men, 30 women), were included in the study. The serum irisin and nesfatin-1 parameters were investigated using blood samples drawn from the patient and control groups.
RESULTS: The mean serum irisin level was 16.87±14.66 ng/mL in the migraine group and 17.33±17.18 ng/mL in the healthy controls. No significant p value was determined (p=0.470), but the level was slightly lower in the migraine group. The mean nesfatin-1 level was 4.71±5.96 mmol/L in the migraine group and 4.13±5.41 mmol/L in the healthy controls (p=0.19), again revealing a small but statistically insignificant difference. In addition, there was no statistically significant difference according to age group, visual analog scale score for pain, body mass index, or length of disease duration.
DISCUSSION AND CONCLUSION: Although no statistically significant differences were observed, the present study is believed to be the first to provide insight on the serum levels of irisin and nesfatin-1 in migraine without aura patients.

Keywords: Headache, irisin, migraine, nesfatin-1

Turan Akdag, Faruk Omer Odabas. Evaluation of serum levels of irisin and nesfatin-1 in patients with migraine without aura. Int J Med Biochem . 2020; 3(2): 67-72

Corresponding Author: Turan Akdag, Türkiye
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