INTRODUCTION: An ascending aortic aneurysm (AsAA) is fundamentally defined as the "ballooning" of the aorta at its exit site from the heart. The condition of PV and endothelial markers in AsAA is also unknown. To investigate AsAA in association with plasma viscosity (PV) and other endothelial markers such as fibrinogen, nitric oxide (NOx) and asymmetric dimethylarginine (ADMA).
METHODS: The study consisted of 23 patients underwent surgical repair for AsAA, and 30 control s without diabetes, hypo- or hyperlipidaemia and heart disease. In this study, several parameters including plasma viscosity (PV), fibrinogen, nitric oxide (NOx) and asymmetric dimethylarginine (ADMA) were assayed in a group of patients with AsAA and control.
RESULTS: Preoperative (preop) PV in patients was significantly higher than postoperative day-7 (postop) and control groups (p<0.05 ). Fibrinogen and ADMA were significantly higher in the control than in the preop group (p<0.001). Postoperative NOx was lower than preoperative NOx (p<0.05).
DISCUSSION AND CONCLUSION: Increase in the PV may cause to have a raise in permeability and glomerular capillary pressure. Fibrinogen level may be reduced in AsAA group as a result of impaired production or increased consumption due to the intravascular coagulation in preop AsAA. The decrease in ADMA is associated with increased NOx, which is a potent inhibitor of platelet aggregation and adhesion to the vessel wall. Preop increase in NOx can be accounted for by an impaired blood flow. Our results suggest that PV and oxidative stress parameters may play a crucial role in the diagnosis, treatment and follow-up of patients with AsAA.