Correlation study between collagen type 1 C telopeptide and thyroid stimulating hormone at the sedentary lifestyle individuals

INTRODUCTION: A sedentary lifestyle can be defined as spending most of your time without physical activity, such as sitting or lying down for long periods during the day. This lifestyle is considered the least energy-consuming state in the
body, which means accumulating a lot of calories in the body. Collagen type 1 C-telopeptide (CTX-1) is the C-terminal telopeptide of fibrillar collagens, such as collagen type I, and has an important role in stabilizing protein tertiary and quaternary structures for bone tissues. It is usually used as a biomarker in serum samples to assess the bone turnover rate. Thyroid-stimulating hormone (TSH) is a peptide hormone secreted by the pituitary gland in the brain. TSH is responsible for sending a signal to the thyroid gland to increase or decrease the amount of hormones it secretes. This study aims to show the correlation between CTX-1 and TSH in individuals who have a sedentary lifestyle, which in turn causes osteoporosis in those individuals. This shows the harms of sedentary lifestyle conditions on individuals.
METHODS: The study was designed based on selecting two groups of male individuals (the first group: 25 individuals living a sedentary lifestyle, and the second group: 25 individuals who have physical activity regularly). Blood samples were collected from all individuals in the study after obtaining their consent. The blood samples of the individuals were used to measure several parameters, including CTX-1, TSH, T4, and T3. The t-test statistical method was used to determine the clinically important values.
RESULTS: The results of the study, after comparing the individuals of the sedentary lifestyle group and the active lifestyle group by the t-test statistical method, showed the following: A significant increase in the level of CTX-1 in the
individuals of the Sedentary Lifestyle Group. A significant decrease in the levels of T3, T4, and TSH in the individuals of the Sedentary Lifestyle Group. The presence of an inverse or negative correlation between CTX-1 and TSH in the individuals of theSedentary Lifestyle Group.
DISCUSSION AND CONCLUSION: The results of this study concluded the importance of physical activity for the body, as the study showed that a sedentary lifestyle causes several disorders, including secondary hypothyroidism, which in turn can cause osteoporosis in individuals.