Int J Med Biochem . 2019; 2(3): 102-106 | DOI: 10.14744/ijmb.2019.20592

The role of serum acute phase reactant levels in the prediction of impacted ureteral stone

Ýsmet Aydýn Hazar¹, Tuncay Tas², Cem Tuðrul Gezmiþ³, Ersan Arda⁴, Nusret Can Çilesiz¹, Basri Cakiroglu^5
1Department of Urology, University of Health Sciences Gaziosmanpasa Taksim Training and Research Hospital, Istanbul, Turkey
²Department of Urology, Esenyurt University Istanbul Cerrahi Hospital, Istanbul, Turkey
³Department of Urology, Public Hospital of Bitlis, Bitlis, Turkey
⁴Department of Urology, Trakya University School of Medicine, Edirne, Turkey
⁵Department of Urology, Hisar Intercontinental Hospital, Istanbul, Turkey

INTRODUCTION: The aim of this study was to investigate the determination of ureteral stone impaction using acute phase reactants.
METHODS: A total of 110 patients who had a single ureteral stone treated during a single month using medical expulsive therapy of tamsulosin 0.4 mg/day, diclofenac 75 mg upon analgesic requirement, and at least 3 liters fluid per day were evaluated prospectively. The patients underwent ureteroscopy and were divided into 2 groups according to the presence or absence of impaction. The preoperative white blood cell (WBC) count, red blood cell distribution width (RDW), C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), mean platelet volume (MPV), and neutrophil-to-lymphocyte ratio (NLR) in the non-impacted stone group (Group 1; n=59) and the impacted group (Group 2; n=51) were statistically compared.
RESULTS: There was no statistically significant difference in terms of age, stone diameter, body mass index, grade of hydronephrosis, or stone localization between the 2 groups. The WBC, RDW, and MPV value differences were statistically significant between the groups (p=0.035, p=0.035, and p=0.005, respectively). An MPV cut-off value of 9.55 fL was defined in Group 2 with 66% sensitivity and 62% specificity for impaction. There was no statistically significant difference between the groups in CRP, ESR, or NLR values (p=0.44, p=0.76, p=0.54, respectively).
DISCUSSION AND CONCLUSION: Evaluation of serum MPV with a cut-off value of 9.55 fL may predict ureteral stone impaction.

Keywords: Impacted, mean platelet volume, red blood cell distribution width, ureteral stone, white blood cell

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