Branched-chain amino acids in obesity and diabetes: Implications and insights
Suria Prabha Kannaiyan1, Arun Prasanna2, Sridevi Chaganti3, Mathi Perin4, Shanthi Dinakar5, Sumod Khedekar6, Sovan Bagchi7, Gautam Deshpande21Department of Pharmaceutics, Chettinad School of Pharmaceutical Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chennai, India2Department of Physical Education and Sports, School of Sports Education and Research, Jain University, Bangalore, India
3Department of Biochemistry, Prathima Relief Institute of Medical Sciences, Hanamkonda, India
4Department of General Medicine, Sree Balaji Medical College and Hospital, Chennai, India
5Department of Biochemistry, Sree Balaji Medical College and Hospital, Chennai, India
6Department of Kaumarbhritya, Gomantak Ayurveda Mahavidyalaya & Research Centre, Goa, India
7Department of Biomedical Sciences, Gulf Medical University, Ajman, UAE
Branched-chain amino acids (BCAAs), such as leucine, isoleucine, and valine, are vital in metabolic processes and in regulating energy equilibrium. In obesity and diabetes, BCAAs have been implicated in various metabolic dysfunctions, such as insulin resistance and altered glucose metabolism. Elevated BCAA levels are often observed in individuals with these conditions, suggesting a potential link between BCAA metabolism and the etiology of obesity and diabetes. Understanding the implications of BCAAs in these disorders could provide insights into novel therapeutic strategies to improve metabolic health and manage these chronic diseases. Previous reviews on BCAAs in the context of obesity and diabetes have often lacked a comprehensive analysis of their dual role in metabolic pathways. These reviews have focused solely on their positive effects, such as muscle protein synthesis, or potential negative impacts, like insulin resistance. Considering recent research findings and clinical studies, a thorough evaluation of the nuanced effects of BCAAs is necessary. This review seeks to fill these gaps by offering an impartial viewpoint on the metabolic onsequences of BCAAs in individuals with obesity and diabetes, highlighting areas for future research and covering the metabolic role of BCAAs, their impact on feed intake patterns, and biochemical insights into BCAA metabolism. The review also delves into leucine's role in diabetes, examining its therapeutic potential and clinical implications. It also investigates mechanisms linking BCAAs to insulin resistance and BCAAs' relationship to mitochondrial dysfunction in obesity, providing a comprehensive understanding of BCAAs' metabolic effects. Given the rising prevalence of obesity and diabetes, this review is crucial for informing therapeutic strategies and identifying areas for future research.
Keywords: Branched-chain amino acids (BCAAs), diabetes, insulin resistance, metabolic dysfunction, obesity, therapeutic strategiesManuscript Language: English