ISSN  2587-2362  |  E-ISSN  2618-642X
Comparison of Diagon Coag XL and Cobas t 511 analyzers [Int J Med Biochem ]
Int J Med Biochem . 2022; 5(2): 116-119 | DOI: 10.14744/ijmb.2022.40316

Comparison of Diagon Coag XL and Cobas t 511 analyzers

Berrak Güven, Ismail Benice, Murat Can
Department of Biochemistry, Zonguldak Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey

INTRODUCTION: We compared prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and Ddimer test results measured using the Diagon Coag XL coagulation analyzer with Cobas t 511 analyzer.
METHODS: Imprecision studies were performed for the PT, aPTT, fibrinogen, and D-dimer tests used by the Diagon Coag XL analyzer. For the comparison study, we used the leftover citrated plasma from patient samples after routine analysis with Cobas t 511. All of the results were analyzed using the correlation coefficient and Passing–Bablok regression analysis.
RESULTS: Total coefficient of variation obtained for all tests were within the criteria for acceptance. The method comparison study showed a good correlation between the results obtained on Diagon Coag XL and Cobas t 511 analyzers, except for aPTT test. The correlation coefficients obtained were 0.98 for PT, INR, and D-dimer, 0.95 for fibrinogen, and 0.80 for aPTT.
DISCUSSION AND CONCLUSION: For PT, aPTT, fibrinogen, and D-dimer tests, Diagon Coag XL analyzer is suitable for monitoring the coagulation system, and it can be used in clinical laboratories. However, the precision values of tests stated by the manufacturer must be verified.

Keywords: Analytical performance, Cobas t 511, Diagon Coag XL

Corresponding Author: Berrak Güven, Türkiye
Manuscript Language: English
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