Relationship between atherogenic index of plasma, asprosin, and metrnl levels in hemodialysis patients
Meltem Yardım1, Levent Deniz2, Mehmet Akif Saltabas3, Damla Kayalp4, Ramazan Fazıl Akkoç5, Tuncay Kuloğlu61Department of Medical Biochemistry, Yerkoy State Hospital, Yozgat, Türkiye2Department of Medical Biochemistry, University of Health Sciences, Bagcılar Training and Research Hospital, Istanbul, Türkiye
3Department of Internal Medicine, Yerkoy State Hospital, Yozgat, Türkiye
4Department of Medical Biochemistry, Yozgat City Hospital, Yozgat, Türkiye
5Department of Anatomy, Faculty of Medicine, Firat University, Elazig, Türkiye
6Department of Histology and Embryology, Faculty of Medicine, Firat University, Elazig, Türkiye
INTRODUCTION: This study aimed to evaluate the relationship between the atherogenic index of plasma (AIP) and plasma asprosin and metrnl levels in hemodialysis (HD) patients.
METHODS: Forty-eight patients receiving HD treatment with a diagnosis of end-stage renal disease (ESRD) were included. The control group comprised 34 age-, sex-, and body mass index-matched healthy volunteers without a history
of renal disease. ESRD patients were divided into two groups: high-risk (AIP≥0.24) and low-moderate risk (AIP<0.24).
Asprosin and metrnl levels in the plasma of blood samples taken just before dialysis were studied by enzyme-linked immunosorbent assay.
RESULTS: A significant difference was found between the control group [23.3(19.9-27.7 ng/mL)], the low-moderate risk
group [39.3(34.9-40.8 ng/mL)], and the high-risk group [48.1(44.5-49.9 ng/mL)] in terms of asprosin levels (for each p<0.001). Asprosin values of both low-moderate risk and high-risk groups were significantly higher than the controls.
In the high-risk group, plasma asprosin levels were higher than in the low-moderate risk group (p=0.012). Metrnl levels of the high-risk group were found to be lower than both the control and low-risk groups (p<0.001 and p=0.003, respectively). AIP showed a positive relation to asprosin and a negative relation to metrnl.
DISCUSSION AND CONCLUSION: Logistic regression analysis has revealed important insights into the independent relationships between metrnl, asprosin, and high AIP values in HD patients. These findings support the anti-atherogenic potential of metrnl and suggest the potential atherogenic effects of asprosin, highlighting the complex interplay between adipokines and cardiovascular risk in this patient population.
Manuscript Language: English