ISSN  2587-2362  |  E-ISSN  2618-642X
Unmeasurable HbA1c result due to hemoglobinopathy [Int J Med Biochem ]
Int J Med Biochem . 2024; 7(1): 41-44 | DOI: 10.14744/ijmb.2023.59480

Unmeasurable HbA1c result due to hemoglobinopathy

Ayşe Aktas, Belkiz Öngen Ipek, Okan Dikker
Department of Medical Biochemistry, University of Health Sciences, Istanbul Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Türkiye

The aim of this study was to show the interference caused by hemoglobinopathy in the measurement of hemoglobin A1c (HbA1c). In our case presentation, we reported two patients whose HbA1c values were unmeasurable when using our laboratory's cation exchange chromatography. We detected HbSβ+ and HbSC variants by remeasuring the samples with another chromatography instrument. Measurement of HbA1c is a commonly performed procedure for the diagnosis of diabetes and for the assessment of blood glucose control in patients with diabetes. However, various hemoglobinopathies, chronic kidney disease, and abnormalities in red cell turnover rate may interfere with HbA1c quantification.

Keywords: Glycated hemoglobin, HbA1c, hemoglobinopathies, HPLC

Ayşe Aktas, Belkiz Öngen Ipek, Okan Dikker. Unmeasurable HbA1c result due to hemoglobinopathy. Int J Med Biochem . 2024; 7(1): 41-44

Corresponding Author: Belkiz Öngen Ipek, Türkiye
Manuscript Language: English
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