INTRODUCTION: Multiple myeloma (MM) is a malignant proliferation of monoclonal plasma cells in the blood that may also cause renal failure. The most frequent complications of MM are painful pathological fractures, anemia, hyperkalemia, renal failure and recurrent bacterial infections. Seen from this aspect, it is indicated that inflammation is a significant component of the neoplastic process.
METHODS: The present study aims to evaluate the association of monocyte, neutrophil, eosinophil and leucocyte volume values in patients with MM as a retrospective study. Sixty patients with MM aged 64.5±11.2 and 107 healthy control aged 64.9±10.3 years who were admitted to the Polyclinic of Hematology in the Faculty of Medicine of the Selcuk University were included in this study.
RESULTS: The monocyte, lymphocytes, neutrophil volume levels were significantly higher in patients as 175.62±8.06; 95.05±6.08; 152.51±8.18, respectively, compared with the control group 170.41±8.15; 89.78±4.92; 148.19±8.04, respectively. The eosinophil volume levels were 157.5±22.4 in the patients group and 157±17.3 in the control group (p=0.953) The findings obtained in this study suggest that monocyte, lymphocytes, neutrophil volume values except eosinophil volume may be used a potentially prognostic biomarker in patients with Multiple myeloma.
DISCUSSION AND CONCLUSION: The present study aimed to evaluate a biomarker that is easily analyzed. This study suggests that monocyte, lymphocytes, neutrophil volume values except eosinophil volume may be used as a potentially prognostic biomarker in patients with Multiple myeloma. And also, monocyte, lymphocyte and neutrophil volume levels are significant parameters that can be applied lower in cost.