ISSN  2587-2362  |  E-ISSN  2618-642X
International Journal of Medical Biochemistry Evaluation of fetuin-A, CRP, and CRP/fetuin-A values in COVID-19 patients [Int J Med Biochem ]
Int J Med Biochem . 2022; 5(3): 125-131 | DOI: 10.14744/ijmb.2022.83097

Evaluation of fetuin-A, CRP, and CRP/fetuin-A values in COVID-19 patients

Nezahat Kurt1, Fatma Betul Ozgeris2, Omer Faruk Kocak3, Neslihan Yuce4, Zafer Bayraktutan4, Emine Parlak5, Taha Abdulkadir Coban1, Ebubekir Bakan6
1Department of Medical Biochemistry, Erzincan Binali Yildirim University Faculty of Medicine, Erzincan, Türkiye
2Department of Nutrition and Dietetics, Ataturk University Faculty of Healthy Sciences, Erzurum, Türkiye
3Department of Chemical Technology, Ataturk University, Erzurum Vocational Training College, Erzurum, Türkiye
4Department of Medical Biochemistry, Ataturk University Faculty of Medicine, Erzurum, Türkiye
5Department of Infectious Diseases and Clinical Microbiology, Ataturk University Faculty of Medicine, Erzurum, Türkiye
6Department of Medical Biochemistry, Agrı Ibrahim Cecen University Faculty of Medicine, Agrı, Türkiye

INTRODUCTION: Fetuin-A, a glycoprotein with several functions, is also a negative acute phase reactant. The purpose of this study was to investigate levels of serum fetuin-A in coronavirus disease 2019 (COVID-19) patients, its association with disease severity, and whether it has superiority over C-reactive protein (CRP).
METHODS: The research comprised 56 individuals with COVID-19(+) and 30 healthy controls. The COVID-19(+) patient population was split into three subgroups: mild, moderate, and severe. All participants’ serum concentrations of fetuin-A, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were measured using ELISA commercial test kits. In addition, CRP and other biochemical values from biochemistry laboratory data were gathered, and the CRP/fetuin-A ratio was calculated.
RESULTS: The fetuin-A concentration of the COVID-19(+) patient group was shown to be statistically lower than that of the healthy control group. TNF-α and IL-6 levels were found to be significantly different in both groups. While fetuin-A had a higher area under the curve (AUC) value than CRP (0.875 and 0.800, respectively), CRP/fetuin-A had the strongest AUC (0.933).
DISCUSSION AND CONCLUSION: Low serum fetuin-A concentrations in COVID-19 patients suggest that fetuin-A is a negative acute phase reactant for severe acute respiratory syndrome coronavirus 2. Furthermore, fetuin-A alone and CRP/fetuin-A value are both contenders for being more remarkable markers than CRP.

Keywords: Acute phase reactant, COVID-19, CRP, fetuin-A

Nezahat Kurt, Fatma Betul Ozgeris, Omer Faruk Kocak, Neslihan Yuce, Zafer Bayraktutan, Emine Parlak, Taha Abdulkadir Coban, Ebubekir Bakan. Evaluation of fetuin-A, CRP, and CRP/fetuin-A values in COVID-19 patients. Int J Med Biochem . 2022; 5(3): 125-131

Corresponding Author: Nezahat Kurt, Türkiye
Manuscript Language: English
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