ISSN  2587-2362  |  E-ISSN  2618-642X
International Journal of Medical Biochemistry Apolipoprotein E and adiponectin levels in coronary artery disease patients with low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol discordance [Int J Med Biochem ]
Int J Med Biochem . 2021; 4(2): 85-90 | DOI: 10.14744/ijmb.2021.91886

Apolipoprotein E and adiponectin levels in coronary artery disease patients with low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol discordance

Özge Kurmuş1, Aycan Fahri Erkan1, Neslihan Çoban2, Ayşem Kaya3, Evin Ademoğlu4
1Department of Cardiology, Ufuk University, Faculty of Medicine, Ankara, Turkey
2Department of Genetics, Istanbul University, Aziz Sancar Institute for Experimental Medicine, Istanbul, Turkey
3Department of Biochemistry Laboratory, Istanbul University-Cerrahpasa, Institute of Cardiology, Istanbul, Turkey
4Department of Biochemistry, Istanbul University, Faculty of Medicine, Istanbul, Turkey

INTRODUCTION: The aim of this study was to investigate whether serum apolipoprotein E (ApoE) and adiponectin were associated with discordance of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) levels in coronary artery disease (CAD) patients.
METHODS: A total of 243 patients with significant CAD were studied. The fasting levels of serum lipids, plasma ApoE, and adiponectin were measured. The median LDL-C and non-HDL-C values were determined to assess and analyze discordance. Discordance was defined as an LDL-C≥ the median and non-HDL-C< the median, or an LDL-C< the median and a non-HDL-C≥ the median. ApoE and adiponectin were compared between discordant and concordant groups.
RESULTS: Discordance between the LDL-C and the non-HDL-C was observed in 14% of the patients. Although the median adiponectin was lowest in the group with an LDL-C< median and a non-HDL-C≥ the median, and the median ApoE was lowest in the group with an LDL-C≥ median and a non-HDL-C< the median, no statistically significant differences in the ApoE and adiponectin were recorded between the groups (p=0.186 and p=0.161, respectively). Adiponectin was negatively correlated with triglyceride and remnant cholesterol (p<0.001 and p<0.001, respectively).
DISCUSSION AND CONCLUSION: While discordance between the LDL-C and the non-HDL-C in CAD patients (14%) was observed, the plasma ApoE and adiponectin levels were not significantly different between the discordant and concordant groups.

Keywords: Adiponectin, apolipoprotein E, coronary artery disease

Özge Kurmuş, Aycan Fahri Erkan, Neslihan Çoban, Ayşem Kaya, Evin Ademoğlu. Apolipoprotein E and adiponectin levels in coronary artery disease patients with low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol discordance. Int J Med Biochem . 2021; 4(2): 85-90

Corresponding Author: Özge Kurmuş, Türkiye
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