International Journal of Medical BiochemistryEstimated glomerular filtration rate in identifying illness severity in newly admitted patients with COVID-19: A single-center study [Int J Med Biochem ]
Estimated glomerular filtration rate in identifying illness severity in newly admitted patients with COVID-19: A single-center study
Yasemin Ustundag1, Fatma Tuba Engindeniz2, Kağan Huysal1, Rahime Feyza Koloğlu1, Ali Asan3, Nizameddin Koca4, Cuma Bulent Gul5, Canan Erdem6, Cuneyt Eris7, Emine Sevgican31Department of Clinical Biochemistry, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey 2Department of Public Health, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey 3Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey 4Department of Internal Medicine, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey 5Department of Nephrology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey 6Department of Obstetrics and Gynecology, Acıbadem Maslak Hospital, Istanbul, Turkey 7Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey
INTRODUCTION: Early prediction of risk factors for serious illness and death in patients with coronavirus disease 2019 (COVID-19) appears to be a priority. This study aimed to examine whether a single estimated glomerular filtration rate (eGFR) at triage predicts the need for intensive care unit (ICU) admission of patients with COVID-19. METHODS: This retrospective study included data from patients with COVID-19 at the Bursa Yuksek Ihtisas Training and Research Hospital until October 2020. Patients were assigned to two groups according to their eGFR level at admission: group 1 (eGFR >60 mL/min/1.73 m2) and group 2 (eGFR=30-60 mL/min/1.73 m2). RESULTS: The results of 1447 consecutive patients diagnosed with COVID-19 were analyzed at hospital admissions. Of these, 1001 patients who met the study criteria were included in the study. The median age of group 2 was higher than group 1: 69 interquartile range (IQR 23) years versus 39 (IQR 23) years (p<0.01). Patients with an eGFR <60 mL/min/1.73 m2 had lower lymphocyte counts while having higher C-reactive protein, d-dimer, lactate dehydrogenase, and fibrinogen levels. The ICU admissions were significantly higher in patients with a baseline eGFR <60 mL/min/1.73 m2 (42.85%) compared with an eGFR >60 mL/min/1.73 m2 (6.42%, p<0.001). There was a weak negative correlation between eGFR and ICU admission (rho=-0.291, p<0.001). DISCUSSION AND CONCLUSION: The eGFR at admission was strongly correlated with the severity of the disease. Therefore, measuring eGFR in all patients at admission may warrant appropriate triage.
Keywords: COVID-19, glomerular filtration rate, intensive care unit
Corresponding Author: Fatma Tuba Engindeniz, Türkiye Manuscript Language: English